{"id":162,"date":"2025-08-06T12:47:55","date_gmt":"2025-08-06T12:47:55","guid":{"rendered":"https:\/\/stgpfizercovid.wpenginepowered.com\/?page_id=162"},"modified":"2025-11-12T10:19:59","modified_gmt":"2025-11-12T10:19:59","slug":"c5091018-study","status":"publish","type":"page","link":"https:\/\/covid19antiviral-hcp.com\/nl-nl\/c5091018-study\/","title":{"rendered":"ASPIRE-IC (C5091018) Study"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"162\" class=\"elementor elementor-162\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1f602709 leftimagebackground e-flex e-con-boxed e-con e-parent\" data-id=\"1f602709\" data-element_type=\"container\" data-e-type=\"container\" id=\"orangebackground\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-28ed4062 e-con-full e-flex e-con e-child\" data-id=\"28ed4062\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1c1f74c5 indent dutch-only elementor-widget elementor-widget-heading\" data-id=\"1c1f74c5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Researching a potential COVID-19 treatment option for immunocompromised patients<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0a11c72 indent elementor-widget elementor-widget-heading\" data-id=\"0a11c72\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<style>.elementor-element-0a11c72{display:none !important}<\/style>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-389fd82c e-con-full e-flex e-con e-child\" data-id=\"389fd82c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7f652bd9 e-flex e-con-boxed e-con e-parent\" data-id=\"7f652bd9\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-2eba00c8 e-con-full e-flex e-con e-child\" data-id=\"2eba00c8\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3068752f elementor-widget elementor-widget-image\" data-id=\"3068752f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"520\" height=\"550\" src=\"https:\/\/covid19antiviral-hcp.com\/wp-content\/uploads\/2025\/08\/Aspire-IC-Pfizer.png\" class=\"attachment-large size-large wp-image-216\" alt=\"\" srcset=\"https:\/\/covid19antiviral-hcp.com\/wp-content\/uploads\/2025\/08\/Aspire-IC-Pfizer.png 520w, https:\/\/covid19antiviral-hcp.com\/wp-content\/uploads\/2025\/08\/Aspire-IC-Pfizer-284x300.png 284w, https:\/\/covid19antiviral-hcp.com\/wp-content\/uploads\/2025\/08\/Aspire-IC-Pfizer-11x12.png 11w\" sizes=\"(max-width: 520px) 100vw, 520px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7e37325c e-con-full e-flex e-con e-child\" data-id=\"7e37325c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7ececa87 elementor-widget elementor-widget-text-editor\" data-id=\"7ececa87\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>We\u2019re investigating ibuzatrelvir, an oral antiviral, in immunocompromised adults who developed symptoms of COVID-19 within the last 5 days.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-33276b54 elementor-widget elementor-widget-text-editor\" data-id=\"33276b54\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tFor immunocompromised patients, a COVID-19 diagnosis can have a significant impact on their daily lives and can cause prolonged illness, even after previous exposure or vaccination. While current COVID-19 treatments have demonstrated a reduction in the risk of hospitalization,<sup>1<\/sup> there remains a need for additional COVID-19 treatment options that do not require administration in a healthcare setting, are not limited by drug interactions, and may be better tailored to meet the needs of patients with certain underlying conditions.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-27819b41 e-flex e-con-boxed e-con e-parent\" data-id=\"27819b41\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1e40e8da elementor-widget elementor-widget-text-editor\" data-id=\"1e40e8da\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Pfizer ASPIRE-IC is a phase 3 clinical trial evaluating orally administered ibuzatrelvir in adults with symptomatic COVID-19 who are severely immunocompromised.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-58f160c1 elementor-widget elementor-widget-text-editor\" data-id=\"58f160c1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>This clinical trial will evaluate the efficacy and safety of ibuzatrelvir with and without remdesivir compared with remdesivir alone.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3595f120 elementor-widget elementor-widget-text-editor\" data-id=\"3595f120\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Ibuzatrelvir has the potential to be a COVID-19 treatment for immunocompromised patients, if the clinical trial is successful and the investigational medicine is approved by regulators.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9d5b16 elementor-widget elementor-widget-text-editor\" data-id=\"9d5b16\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>[Watch this video to learn more about ibuzatrelvir and the ASPIRE-IC clinical trial:]<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6ca5c27 e-flex e-con-boxed e-con e-parent\" data-id=\"6ca5c27\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-176e4c4 elementor-widget elementor-widget-video\" data-id=\"176e4c4\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;video_type&quot;:&quot;hosted&quot;,&quot;controls&quot;:&quot;yes&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"e-hosted-video elementor-wrapper elementor-open-inline\">\n\t\t\t\t\t<video class=\"elementor-video\" src=\"\/wp-content\/uploads\/2025\/08\/C5091018_HCP_Video_US_EN.mp4\" controls=\"\" preload=\"metadata\" controlsList=\"nodownload\" poster=\"https:\/\/covid19antiviral-hcp.com\/wp-content\/uploads\/2025\/08\/Aspire-IC-Video-Placeholder.png\"><\/video>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c694fbf leftimagebackground e-flex e-con-boxed e-con e-parent\" data-id=\"c694fbf\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-50adb4dc e-con-full e-flex e-con e-child\" data-id=\"50adb4dc\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5bf1dac elementor-widget elementor-widget-heading\" data-id=\"5bf1dac\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Participant eligibility<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-571735ff elementor-widget elementor-widget-text-editor\" data-id=\"571735ff\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>This clinical trial is enrolling participants who:<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-67805de5 elementor-widget elementor-widget-text-editor\" data-id=\"67805de5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul>\n \t<li>Are adults at least 18 years of age<\/li>\n \t<li>Have COVID-19 and developed signs\/symptoms within the last 5 days<\/li>\n \t<li>Are immunocompromised due to:\n<ul>\n \t<li>Solid organ or islet cell transplant recipient who is receiving immunosuppressive therapy;<\/li>\n \t<li>Active hematologic malignancy (e.g., chronic lymphocytic lymphoma, non-Hodgkin lymphoma, multiple myeloma, acute leukemia);<\/li>\n \t<li>Receipt of CAR-T-cell therapy or HCT either within 2 years of transplantation or who are receiving immunosuppressive therapy;<\/li>\n \t<li>Currently receiving B-cell depleting therapies (e.g., rituximab, ocrelizumab, ofatumumab, epratuzumab)<\/li><\/ul>\n<li>Are not currently receiving antiviral treatment for COVID-19<\/li>\n<\/ul>\n<\/li>\n<\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-71d02690 elementor-widget elementor-widget-text-editor\" data-id=\"71d02690\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Additional requirements apply. Only Principal Investigators can determine eligibility.\u00a0\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-46645c7c e-con-full e-flex e-con e-child\" data-id=\"46645c7c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-40c89f3a e-flex e-con-boxed e-con e-parent\" data-id=\"40c89f3a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-4e85ae4b e-con-full e-flex e-con e-child\" data-id=\"4e85ae4b\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2f03a635 elementor-widget elementor-widget-image\" data-id=\"2f03a635\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"520\" height=\"674\" src=\"https:\/\/covid19antiviral-hcp.com\/wp-content\/uploads\/2025\/08\/Aspire-IC-about-clinical-trial.png\" class=\"attachment-large size-large wp-image-218\" alt=\"\" srcset=\"https:\/\/covid19antiviral-hcp.com\/wp-content\/uploads\/2025\/08\/Aspire-IC-about-clinical-trial.png 520w, https:\/\/covid19antiviral-hcp.com\/wp-content\/uploads\/2025\/08\/Aspire-IC-about-clinical-trial-231x300.png 231w, https:\/\/covid19antiviral-hcp.com\/wp-content\/uploads\/2025\/08\/Aspire-IC-about-clinical-trial-9x12.png 9w\" sizes=\"(max-width: 520px) 100vw, 520px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-40dbd1ab e-con-full e-flex e-con e-child\" data-id=\"40dbd1ab\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4acb6a7a elementor-widget elementor-widget-heading\" data-id=\"4acb6a7a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">About the clinical trial<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-70c986 elementor-widget elementor-widget-text-editor\" data-id=\"70c986\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Participants will be randomized 1:1:1 to receive oral ibuzatrelvir for the duration of the treatment period, intravenous remdesivir (once daily infusions for 3 days), or a combination of both. The treatment period will be discussed with the participant by the trial doctor. All participants may receive supportive therapy for symptom management including antipyretics, analgesics, antitussives, and antiemetics.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-29bb65db elementor-widget elementor-widget-text-editor\" data-id=\"29bb65db\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Participants will be enrolled for approximately 6 months and will need to attend at least 10 appointments.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-782e5c4e elementor-widget elementor-widget-text-editor\" data-id=\"782e5c4e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>[There is no cost to participate, and health insurance is not required. Participants will be reimbursed for any reasonable expenses they may have as a result of taking part in this clinical trial (e.g., parking, travel, etc.).]<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6a23bd60 leftimagebackground e-flex e-con-boxed e-con e-parent\" data-id=\"6a23bd60\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-3e9d3a19 e-con-full e-flex e-con e-child\" data-id=\"3e9d3a19\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1ba071f0 elementor-widget elementor-widget-heading\" data-id=\"1ba071f0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Together, we can make a difference<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-683d8576 elementor-widget elementor-widget-text-editor\" data-id=\"683d8576\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>People are often introduced to clinical trials through conversations with their healthcare providers. We appreciate you taking the time to have discussions with your patients and their loved ones who may be interested in contributing to research.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-20b30fc elementor-widget elementor-widget-text-editor\" data-id=\"20b30fc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<style>.elementor-element-20b30fc{display:none !important}<\/style>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4b390cb6 elementor-widget elementor-widget-text-editor\" data-id=\"4b390cb6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Should any of your patients take part in this clinical trial, they will have the option to remain under your medical care for all non-study-related needs.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-31308e43 elementor-widget elementor-widget-text-editor\" data-id=\"31308e43\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Thank you for considering your patients for this important clinical trial.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-563d24b5 e-con-full e-flex e-con e-child\" data-id=\"563d24b5\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-50a505cf e-flex e-con-boxed e-con e-parent\" data-id=\"50a505cf\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7446e561 e-con-full e-flex e-con e-child\" data-id=\"7446e561\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9288bc7 elementor-widget elementor-widget-image\" data-id=\"9288bc7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"520\" height=\"562\" src=\"https:\/\/covid19antiviral-hcp.com\/wp-content\/uploads\/2025\/08\/Aspire-IC-ibuzatrelvir.png\" class=\"attachment-large size-large wp-image-220\" alt=\"\" srcset=\"https:\/\/covid19antiviral-hcp.com\/wp-content\/uploads\/2025\/08\/Aspire-IC-ibuzatrelvir.png 520w, https:\/\/covid19antiviral-hcp.com\/wp-content\/uploads\/2025\/08\/Aspire-IC-ibuzatrelvir-278x300.png 278w, https:\/\/covid19antiviral-hcp.com\/wp-content\/uploads\/2025\/08\/Aspire-IC-ibuzatrelvir-11x12.png 11w\" sizes=\"(max-width: 520px) 100vw, 520px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7af4ca08 e-con-full e-flex e-con e-child\" data-id=\"7af4ca08\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2fac9d6c dutch-only elementor-widget elementor-widget-heading\" data-id=\"2fac9d6c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Ibuzatrelvir mechanism of action<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-69c00e0e elementor-widget elementor-widget-text-editor\" data-id=\"69c00e0e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Ibuzatrelvir is a selective inhibitor of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro), a virally encoded enzyme that is critical to the SARS-CoV-2 replication cycle.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3ab644f1 elementor-widget elementor-widget-text-editor\" data-id=\"3ab644f1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>In earlier clinical trials, ibuzatrelvir was observed to reduce SARS-CoV-2 viral RNA levels in patients with COVID-19 through inhibition of viral replication.<sup>2<\/sup> Prior studies demonstrate that inhibition of viral replication has the potential to correlate with positive clinical outcomes including prevention of disease progression and decreased rates of hospitalization and death.<sup>3, 4<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-bf8801e e-flex e-con-boxed e-con e-parent\" data-id=\"bf8801e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b54b912 elementor-widget elementor-widget-text-editor\" data-id=\"b54b912\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Additionally, we are researching whether ibuzatrelvir\u2019s lower potential for drug-drug interactions may benefit patients who take other medications for overlapping health conditions.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-20ea904 elementor-widget elementor-widget-text-editor\" data-id=\"20ea904\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<style>.elementor-element-20ea904{display:none !important}<\/style>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3109a1b8 elementor-widget elementor-widget-text-editor\" data-id=\"3109a1b8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><em>Ibuzatrelvir is investigational and has not been approved by any health authority. <\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-43d76ffc orangetransparentbackground e-flex e-con-boxed e-con e-parent\" data-id=\"43d76ffc\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-739b398e elementor-widget elementor-widget-heading\" data-id=\"739b398e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Do you have immunocompromised patients with COVID-19 in your care?<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4097f096 elementor-widget elementor-widget-text-editor\" data-id=\"4097f096\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>To learn more about Pfizer\u2019s Antiviral COVID-19 Clinical Trials and how to refer potentially eligible patients, please complete the contact form and a member of the Pfizer [Field Medical] team will contact you.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a06c651 elementor-widget elementor-widget-text-editor\" data-id=\"a06c651\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>LoremBeforeCF<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1335ec6d elementor-widget elementor-widget-button\" data-id=\"1335ec6d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/home#contact\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Contact Form<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2cd0cfb0 elementor-widget elementor-widget-text-editor\" data-id=\"2cd0cfb0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Thank you for considering Pfizer\u2019s Antiviral COVID-19 Clinical Trials for your patients.\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-68c6bcc2 e-flex e-con-boxed e-con e-parent\" data-id=\"68c6bcc2\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7146b4e8 elementor-widget elementor-widget-heading\" data-id=\"7146b4e8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Site finder<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5093a836 elementor-widget elementor-widget-text-editor\" data-id=\"5093a836\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Find an ASPIRE-IC study site near you<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-75b1327 elementor-widget elementor-widget-text-editor\" data-id=\"75b1327\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The ASPIRE-IC clinical trial is taking place in multiple countries worldwide.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-59232e13 elementor-widget elementor-widget-text-editor\" data-id=\"59232e13\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>To find your nearest study site, please enter your postal code and select the optimal distance to view on the map from the drop-down menu:<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6d4edecb elementor-widget elementor-widget-shortcode\" data-id=\"6d4edecb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"shortcode.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-shortcode\">\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n <style>\r\n\t#wpsl-stores .wpsl-store-thumb {height:45px !important; width:45px !important;}\r\n\t#wpsl-stores, #wpsl-direction-details, #wpsl-gmap {height:650px !important;}\r\n\t#wpsl-gmap .wpsl-info-window {max-width:250px !important;}\r\n\t.wpsl-input label, #wpsl-radius label, #wpsl-category label {width:200px;}\r\n\t#wpsl-search-input  {width:200px;}\r\n<\/style>\r\n<div id=\"wpsl-wrap\">\r\n\t<div class=\"wpsl-search wpsl-clearfix \">\r\n\t\t<div id=\"wpsl-search-wrap\">\r\n\t\t\t<form autocomplete=\"off\">\r\n\t\t\t<div class=\"wpsl-input\">\r\n\t\t\t\t<div><label for=\"wpsl-search-input\">Your location<\/label><\/div>\r\n\t\t\t\t<input id=\"wpsl-search-input\" type=\"text\" value=\"\" name=\"wpsl-search-input\" placeholder=\"\" aria-required=\"true\" \/>\r\n\t\t\t<\/div>\r\n\t\t\t<div class=\"wpsl-select-wrap\">\r\n\t\t\t\t<div id=\"wpsl-radius\">\r\n\t\t\t\t\t<label for=\"wpsl-radius-dropdown\">Search radius<\/label>\r\n\t\t\t\t\t<select id=\"wpsl-radius-dropdown\" class=\"wpsl-dropdown\" name=\"wpsl-radius\">\r\n\t\t\t\t\t\t<option value=\"10\">10 km<\/option><option value=\"25\">25 km<\/option><option value=\"50\">50 km<\/option><option value=\"100\">100 km<\/option><option selected=\"selected\" value=\"200\">200 km<\/option><option value=\"500\">500 km<\/option>\r\n\t\t\t\t\t<\/select>\r\n\t\t\t\t<\/div>\r\n\t\t\t<\/div>\r\n\t\t\t\t<div class=\"wpsl-search-btn-wrap\"><input id=\"wpsl-search-btn\" type=\"submit\" value=\"Search\"><\/div>\r\n\t\t<\/form>\r\n\t\t<\/div>\r\n\t<\/div>\r\n\t<div id=\"wpsl-gmap\" class=\"wpsl-gmap-canvas\"><\/div>\r\n\t<div id=\"wpsl-result-list\">\r\n\t\t<div id=\"wpsl-stores\" >\r\n\t\t\t<ul><\/ul>\r\n\t\t<\/div>\r\n\t\t<div id=\"wpsl-direction-details\">\r\n\t\t\t<ul><\/ul>\r\n\t\t<\/div>\r\n\t<\/div>\r\n<\/div>\r\n \n\n<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-652fc2e7 orangetransparentbackground e-flex e-con-boxed e-con e-parent\" data-id=\"652fc2e7\" data-element_type=\"container\" data-e-type=\"container\" id=\"references\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6fbb15ba elementor-widget elementor-widget-heading\" data-id=\"6fbb15ba\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">References<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-15ae084b elementor-widget elementor-widget-text-editor\" data-id=\"15ae084b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>1. Centers for Disease Control and Prevention. COVID-19 Treatment Clinical Care for Outpatients. CDC. Published December 20, 2024. Accessed March 28, 2025.\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1a713ad1 elementor-widget elementor-widget-text-editor\" data-id=\"1a713ad1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.cdc.gov\/covid\/hcp\/clinical-care\/outpatient-treatment.html\" rel=\"noopener\">https:\/\/www.cdc.gov\/covid\/hcp\/clinical-care\/outpatient-treatment.html<\/a>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e0445cc elementor-widget elementor-widget-text-editor\" data-id=\"e0445cc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>2. A Study to Understand the Effect and Safety of the Study Medicine PF-07817883 in Adults Who Have Symptoms of COVID-19 But Are Not Hospitalized. ClinicalTrials.gov identifier: NCT05799495. Updated October 9, 2024. Accessed March 6, 2025.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6835c12c elementor-widget elementor-widget-text-editor\" data-id=\"6835c12c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05799495\" target=\"_blank\" rel=\"noopener\">https:\/\/clinicaltrials.gov\/study\/NCT05799495<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-10bb1ff6 elementor-widget elementor-widget-text-editor\" data-id=\"10bb1ff6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>3. Evaluation of Protease Inhibition for COVID-19 in Standard-Risk Patients (EPIC-SR). ClinicalTrials.gov identifier: NCT05011513. Updated August 14, 2023. Accessed March 13, 2025.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-53f9e3c elementor-widget elementor-widget-text-editor\" data-id=\"53f9e3c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05011513\" target=\"_blank\" rel=\"noopener\">https:\/\/clinicaltrials.gov\/study\/NCT05011513<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-77e42f61 elementor-widget elementor-widget-text-editor\" data-id=\"77e42f61\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>4. EPIC-HR: Study of Oral PF-07321332\/\u200bRitonavir Compared With Placebo in Nonhospitalized High Risk Adults With COVID-19. ClinicalTrials.gov identifier: NCT04960202. Updated February 9, 2023. Accessed March 13, 2025.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-50cc0abf elementor-widget elementor-widget-text-editor\" data-id=\"50cc0abf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT04960202\" target=\"_blank\" rel=\"noopener\">https:\/\/clinicaltrials.gov\/study\/NCT04960202<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Researching a potential COVID-19 treatment option for immunocompromised patients We\u2019re investigating ibuzatrelvir, an oral antiviral, in immunocompromised adults who developed symptoms of COVID-19 within the last 5 days. For immunocompromised patients, a COVID-19 diagnosis can have a significant impact on their daily lives and can cause prolonged illness, even after previous exposure or vaccination. While [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-162","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/covid19antiviral-hcp.com\/nl-nl\/wp-json\/wp\/v2\/pages\/162","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/covid19antiviral-hcp.com\/nl-nl\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/covid19antiviral-hcp.com\/nl-nl\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/covid19antiviral-hcp.com\/nl-nl\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/covid19antiviral-hcp.com\/nl-nl\/wp-json\/wp\/v2\/comments?post=162"}],"version-history":[{"count":0,"href":"https:\/\/covid19antiviral-hcp.com\/nl-nl\/wp-json\/wp\/v2\/pages\/162\/revisions"}],"wp:attachment":[{"href":"https:\/\/covid19antiviral-hcp.com\/nl-nl\/wp-json\/wp\/v2\/media?parent=162"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}